Ribocentre-FoldBridge 数据库发布，连接 RNA 化学探测数据与三维结构
Ribocentre-FoldBridge: a comprehensive database bridging RNA chemical probing data and 3D structures
Ribocentre-FoldBridge 是一个经人工审编、AI 辅助的数据库，把整理后的 RNA 化学探测图谱与实验解析的三维结构关联起来。该数据库收录 12 类 RNA，将 5 类实验的 256 929 条探测图谱与 5321 个结构关联案例相连，并可在核苷酸分辨率上交互查看与 RNA 二级、三级结构对齐的探测图谱。作者展示了配对、未配对和溶剂可及等结构情境下探针特异的反应性模式。数据库旨在为跨异质实验考察 RNA 结构与功能关系提供可复现的证据层，并推动新的 RNA 结构或功能预测程序开发。
来源：Nucleic Acids Research · doi.org
RNA chemical probing generates nucleotide-resolved profiles in vitro and in cells, while X-ray crystallographic or cryo-electron microscopy models provide high-resolution structural models but remain comparatively low throughput. Aligning these experiments from different modalities may provide insights into RNA structure formation and molecular functions. Here, we present Ribocentre-FoldBridge (https://foldbridge.ribocentre.org/), an AI-assisted, curator-reviewed database linking curated chemical-probing profiles with experimentally determined 3D structures. This database catalogues 12 types of RNAs, linking 256 929 probing profiles across five experimental categories to 5321 structure-linked cases. It interactively visualizes the probing profiles that align with RNA secondary and tertiary structures at nucleotide resolution. We demonstrate probe-specific reactivity patterns across paired, unpaired, and solvent-accessible structural contexts. The database aims to provide a reproducible evidence layer for examining RNA structure–function relationships across heterogeneous experiments, and thus facilitate the development of new RNA structure or function prediction programs.