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eLife·· 5 天前精选AI 评分40

女性健康研究的新悖论:纳入标准如何反而抬高研究门槛

The new paradox of women’s health research

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文章讨论女性健康研究中的一个悖论:推动研究纳入女性的努力本意是加强女性健康研究,但当严格纳入被理解为必须做详尽的激素或生殖特征刻画时,即便研究问题并不需要这些细节,也可能让涉及女性的研究更难开展。作者主张特征刻画的程度应与研究要支持的结论相匹配,并认为资助方、机构和期刊需提供资源让这种严谨可行,方法学进步应拓宽而非收窄女性健康所需的证据基础。

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来源:eLife · doi.org

推荐理由

文章讨论女性健康研究中纳入标准与激素表征要求之间的张力,提出表征程度应与研究要支持的结论相匹配。

论文摘要 · 原文

Women have long been underrepresented in biomedical research, prompting efforts to make research more sex inclusive. These advances are essential, but they can create an unintended tension when rigorous inclusion is interpreted as requiring extensive hormonal or reproductive characterization, even when such detail is unnecessary for the question being asked. We examine this paradox, in which standards intended to strengthen research on women may inadvertently make some studies involving females harder to pursue. We argue that characterization should match the claim a study is designed to support, and that funders, institutions and journals must provide the resources needed to make such rigor feasible. Methodological progress should ultimately broaden, not narrow, the evidence base needed to improve women’s health.