Cell Reports Medicine· Yueyue Fan, Jiamin Ye, Yuanfang Chen, Gaoli Niu, Mengbin Ding, Ruiyan Li, Li Wang, Yong Kang, Xiangyang Yu, Xiaoyuan Ji·· 17 小时前AI 评分46
工程化肝细胞微纳机器人经糖异生靶向清除乳酸以增强放疗敏感性并激活免疫
Targeted lactate depletion via gluconeogenesis by engineered hepatocyte-based micronanorobots for radiosensitization and immune activation
AI 导读
Fan 等将 CXCR4 工程化肝细胞胞质体与 Au-Pt 纳米机器人整合，通过糖异生清除肿瘤乳酸。乳酸清除抑制修复相关乳酰化并削弱 MRN 介导的 DNA 修复，Au-Pt 催化则放大辐射损伤。该代谢重塑同时缓解免疫抑制并促进全身抗肿瘤免疫。
阅读原文
来源：Cell Reports Medicine · cell.com