dictyBase 2026：在极简基础设施上重构盘基网柄菌模式生物数据库
dictyBase 2026: a reimplementation of the Dictyostelium model organism database on minimal infrastructure
dictyBase 2026 将盘基网柄菌（Dictyostelium discoideum）模式生物数据库完整重构为不依赖数据库服务器的自包含服务，改用静态数据文件。每个基因记录页整合了人工审编的功能、人类疾病关联、发育期表达和蛋白结构信息，站点提供序列搜索、基因组浏览、富集分析和实验设计工具。Dicty Stock Center 全部 7055 株菌株和 1265 个质粒的目录已纳入并可在站内订购。文献注释采用作者参与流程：语言模型起草注释，论文作者修正，再由审编员批准；分析可仅基于审编员批准的注释，也可扩展至待审注释。
来源：Nucleic Acids Research · doi.org
Dictyostelium discoideum is a model organism used to investigate a wide array of biological processes including chemotaxis, cell motility, phagocytosis, multicellular development, and autophagy. Many of its genes have human orthologs implicated in disease, making it a useful model organism for studying conditions ranging from cancer to neurodegeneration. dictyBase has served this community for two decades as a home for genomic data, protocols, a stock center, and community news. Here we describe a complete reimplementation of dictyBase as a self-contained service that uses static data files rather than a database server. Each gene record gathers curated function, human-disease context, developmental expression, and protein structure in a single webpage. The site also provides tools for sequence search, genome browsing, enrichment analysis, and experimental design. The complete Dicty Stock Center catalog of 7055 strains and 1265 plasmids is included, and both can be ordered from the site. New literature is curated by an author-in-the-loop pipeline. A language model drafts the annotations, the authors of the paper correct them, and a curator approves them. Analyses can be run on curator-approved annotations alone or extended to include those still awaiting review. dictyBase is freely available at https://dicty.org.