Cell Genomics· Seunghyun Wang, Mingyun Bae, Jinhao Wang, Boxun Zhao, Khue Nguyen, Shayna Mallett, Jessica A. Switzenberg, Steven J. Losh, Corinne E. Sexton, Benpeng Miao, Shihua Dong, Xi Zeng, Ziying Wang, Torrin L. McDonald, Camille Mumm, Rohini K. Gadde, Arnaz Maryam Tariq, Zhuofu Chen, William C. Feng, Aidan Burn, Junseok Park, Chong Chu, Hui Shen, Ting Wang, Alexander E. Urban, Xiaowei Zhu, Heng Li, Kathleen H. Burns, Hye-Jung E. Chun, Peter J. Park, SMaHT MEI Working Group, Alan P. Boyle, Ryan E. Mills, Weichen Zhou, Eunjung Alice Lee·· 19 小时前AI 评分60
多平台框架实现人体组织体细胞逆转座插入的定位与溯源
Multi-platform framework for mapping somatic retrotransposition in human tissues
AI 导读
Wang 等人建立了一个经系统基准评测的多平台框架，整合长读长测序与基因组组装，用于准确检测体细胞移动元件插入并追溯其来源。将该框架应用于正常人体组织后，研究检出罕见的体细胞 L1 插入，为研究移动元件在生命过程中如何改变基因组提供了手段。
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来源：Cell Genomics · cell.com