Cell Reports Medicine· Qing Zhang, Simeng Li, Mengting Xu, Hanchi Xu, Haiyang Zhou, Hongmei Hu, Dianping Yu, Linyang Li, Xiaoyu Tao, Xuwen Lin, Xinru Li, Shize Xie, Xinying Xue, Qun Wang, Tao Yang, Weidong Zhang, Sanhong Liu·· 1 天前AI 评分42
异补骨脂查尔酮靶向去泛素化酶 OTUB1 诱导 PD-L1 降解并增强抗肿瘤免疫
Isobavachalcone targets deubiquitinase OTUB1 to induce PD-L1 degradation and enhances antitumor immunity
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Zhang 等发现异补骨脂查尔酮靶向去泛素化酶 OTUB1，促进癌细胞中 PD-L1 的泛素化与降解。该调控增强 T 细胞介导的抗肿瘤免疫，重塑肿瘤免疫微环境并抑制肿瘤生长。
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来源：Cell Reports Medicine · cell.com