Cell Reports Medicine· Jiao Hu, Yifan Liu, Minfeng Chen, Jiantu Ou, Tongchen He, Jinhui Liu, Minghui Hu, Bohan Zhou, Huihuang Li, Luzhe Yan, Jiatong Xiao, Zhenyu Nie, Zhiyong Cai, Peihua Liu, Dingshan Deng, Yunbo He, Benyi Fan, Zhenyu Ou, Ruizhe Wang, Guanghui Gong, Xiao Guan, Shiyu Tong, Yangle Li, Wei He, Zefu Liu, Yuanqing Dai, Bolong Liu, Xiaogen Kuang, Tao Guo, Lunquan Sun, Xiaohua Yao, Junhao Yu, Hengyun Wang, Jinbo Chen, Xiongbing Zu·· 18 小时前AI 评分62
膀胱癌新辅助免疫治疗中肿瘤微环境的时空动态演化
Spatiotemporal dynamic evolution of the tumor microenvironment during neoadjuvant immunotherapy for bladder cancer
AI 导读
Hu 等绘制了膀胱癌新辅助免疫治疗过程中肿瘤微环境的表型演化图谱。治疗驱动肿瘤细胞走向不同命运，形成免疫治疗诱导的肿瘤-髓系屏障，促进 T 细胞终末耗竭，并诱导衰老型 iCAF 表型。SERPINH1 被提出作为获得性耐药的潜在治疗靶点。
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来源：Cell Reports Medicine · cell.com