Cell Reports Medicine· Siyuan Luan, Jun Sun, Yijun Dong, Jin Tan, Xin Xiao, Jintong Zhang, Xiaokun Li, Jianfeng Zhou, Pinhao Fang, Haowen Zhang, Shangwei Sun, Zewen Wang, Jian Wang, Tara SR. Chen, Xiaoting Chen, Yushang Yang, Haopeng Yu, Hui Yang, Longqi Chen, Xiaoxi Zeng, An-Yuan Guo, Junjun Ding, Yong Yuan·· 22 小时前AI 评分60
靶向致癌 SOX2 凝聚体可抑制鳞状细胞癌进展
Targeting oncogenic SOX2 condensates suppresses squamous cell carcinoma progression
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Luan 等发现 SOX2 凝聚体通过调控染色质组织和致癌基因表达促进鳞状细胞癌（SCC）进展。FDA 已批准的药物 ixazomib 能以依赖 HSP70 的方式选择性破坏 SOX2 凝聚体，提供了一种针对 SCC、可由生物标志物指导的治疗策略。
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来源：Cell Reports Medicine · cell.com