MetabDB 数据库发布，整合人类代谢指标、疾病关联与遗传证据
MetabDB: an integrated resource for human metabolic measures, disease associations, and genetic evidence
MetabDB 是一个整合人类代谢指标、疾病关联与遗传证据的数据库，已整合 16 项公开研究，覆盖核磁共振、质谱和脂质组学平台。当前版本收录 2663 个代谢指标、3524 种疾病与结局、3382 个其他全基因组关联性状和 2025 个分子数量性状位点（QTL）靶标。该数据库通过变异/QTL 关联、精细定位、罕见变异或负荷分析、共定位、孟德尔随机化和群体关联，把基因组变异、基因与蛋白、代谢指标和疾病或性状连接起来；代谢指标保留来源报告的形式，包括化合物、脂质种类、脂蛋白指标、比值、百分比和衍生性状。
来源：Nucleic Acids Research · doi.org
Population-scale metabolomics studies have linked metabolic measures to diseases, quantitative traits, and genetic variation, but the results are scattered across assay platforms, phenotype definitions, and analytical formats. MetabDB integrates 16 public studies spanning nuclear magnetic resonance, mass spectrometry, and lipidomics. The current release contains 2663 metabolic measures, 3524 diseases and outcomes, 3382 other genome-wide association traits, and 2025 molecular quantitative trait locus (QTL) targets. MetabDB links genomic variants, genes and proteins, metabolic measures, and diseases or traits through variant/QTL associations, fine-mapping, rare-variant or burden analyses, colocalization, Mendelian randomization, and population associations. Metabolic measures areretained in their source-reported forms, including compounds, lipid species, lipoprotein measures, ratios, percentages, and derived traits. Gene- and protein-level evidence can be examined alongside genomic signals and related disease or trait evidence for the same metabolic measure. Source information and reported analytical details are retained, including the source study, original variable or phenotype definition, assay, unit, exposure scale, analytical model, and statistics where available. Search, browse, and colocalization pages, together with gene evidence breadth and disease-association profiles, provide access to these records. MetabDB is freely available at http://www.mulinlab.org/metabdb/.