lncRNAfunc 2.0 发布：整合多源证据解读癌症 lncRNA 功能
LncRNAfunc 2.0: an evidence-integrated knowledgebase for regulatory and functional interpretation of lncRNAs in cancer
lncRNAfunc 2.0 发布，这是一个通过多源证据整合来系统解读癌症 lncRNA 功能的更新版知识库。相比上一版，它重新处理了来自 The Cancer Genome Atlas 的泛癌数据，纳入 GTEx 的正常组织背景和 CCLE 的癌细胞系背景，大幅扩充了结合与互作证据，并新增 lncRNA 及其调控因子的扰动证据。这些资源与基于关联的分析和计算预测整合，作为解读 lncRNA 调控关系的互补证据。
来源：Nucleic Acids Research · doi.org
Long non-coding RNAs (lncRNAs) play diverse regulatory roles in cancer, yet their functional interpretation remains largely based on molecular associations and computational predictions, while experimentally derived evidence is fragmented across heterogeneous resources. Here, we present lncRNAfunc 2.0, an updated knowledgebase for systematic functional interpretation of cancer lncRNAs through multi-source evidence integration. Compared with the previous version, lncRNAfunc 2.0 reprocesses pan-cancer data from The Cancer Genome Atlas, incorporates normal-tissue and cancer-cell-line contexts from GTEx and CCLE, substantially expands binding and interaction evidence, and introduces perturbation evidence for lncRNAs and their regulators. These resources are integrated with association-based analyses and computational predictions as complementary evidence for interpreting lncRNA-associated regulatory relationships. lncRNAfunc 2.0 organizes functional knowledge into six biological dimensions: dysregulation, upstream regulation, lncRNA-mediated mRNA regulation, transcript remodeling, protein regulation, and tumor phenotypes. This framework connects regulatory determinants of lncRNAs with their downstream molecular relationships and phenotypic associations, including mRNA regulation, alternative splicing, protein regulation, survival, molecular and immune phenotypes, and drug response. Overall, lncRNAfunc 2.0 provides an evidence-integrated framework for exploring context-dependent lncRNA functions and regulatory mechanisms across cancers. lncRNAfunc 2.0 is freely available at https://lncrnafunc.xu-bioinfo.com/.