ArthroVerse 数据库发布，绘制节肢动物相关微生物组蛋白家族多样性
ArthroVerse: mapping protein family diversity across arthropod-associated microbiomes
ArthroVerse 是首个基于节肢动物相关微生物宏基因组构建的蛋白家族综合数据库。研究者对序列做严格过滤、去冗余和聚类，得到非冗余蛋白家族，并为其补充微生物分类、宿主关联、蛋白结构信息以及碳水化合物活性酶预测。该数据集同时整合宏基因组来源蛋白与参考基因组来源蛋白，可用于系统探索昆虫微生物组的功能多样性、进化关系与宿主—微生物互作。数据库公开访问，作者称其可为微生物生态与节肢动物生理研究提供资源。
来源：Nucleic Acids Research · doi.org
Metagenomic studies of arthropod-associated microbiomes have generated vast amounts of sequence data, yet the functional and structural organization of these proteins remains largely unexplored. Here, we present ArthroVerse, the first comprehensive database of protein families derived from arthropod-associated metagenomes. Non-redundant protein families were generated after rigorous filtering, deduplication, and clustering. The protein families were further annotated with microbial taxonomy, host associations, protein structural information, and carbohydrate-active enzymes predictions. The resulting dataset integrates both metagenomic and reference genome-derived proteins, enabling systematic exploration of functional diversity, evolutionary relationships, and host-microbe interactions in insect microbiomes. ArthroVerse provides a valuable resource for the study of microbial ecology and arthropod physiology, offering unprecedented insight into the protein landscape of insect-associated microbial communities. ArthroVerse is publicly accessible at https://envofams.org/arthroverse/.