LoGIC 数据库发布跨物种局部基因簇整合目录
LoGIC: a cross-species local gene-cluster integrative catalog
LoGIC（Local Gene-cluster Integrative Catalog）是一个跨物种局部同源基因簇整合数据库，收录了从30个代表性真核物种中鉴定出的20 306个局部基因簇。除每个基因簇的基本基因组特征外，用户还可以查看簇内基因成员的序列相似性、同一物种内成簇基因的功能偏好，以及基因簇的跨物种保守性。针对人类基因簇，数据库还提供组织范围表达谱以及与染色质 Hi-C 结构关系的信息。作者表示，LoGIC 可用于串联基因重复、旁系同源基因功能分化、谱系特异性基因家族扩张以及同源基因簇跨物种演化保守或重塑等研究。
来源：Nucleic Acids Research · doi.org
Homologous genes, especially those sharing close genomic locations and forming gene clusters, often have compensatory roles, therefore pose remarkable challenges for deciphering the functions and relationships of these genes. A comprehensive database of local homologous gene clusters with multimodal information would greatly facilitate such research. Here, we present LoGIC (https://omicslab.genetics.ac.cn/LoGIC/), a Local Gene-cluster Integrative Catalog that includes 20 306 local gene clusters identified from 30 representative eukaryotic species. In addition to the basic genomic features of each gene cluster, LoGIC also allows users to examine the sequence similarity of gene members within a cluster, the functional preference of clustered genes within a species, and the cross-species conservation of gene clusters. Information of tissue-wide expression profile and relationship with chromatin Hi-C structure is also available for human gene clusters. Together, LoGIC can facilitate studies of tandem gene duplication, paralog functional divergence, lineage-specific gene-family expansion, and evolutionary conservation or remodelling of homologous gene clusters across-species.